Information about Prokarin
The number one variable in the effectiveness of Prokarin
The consistency (thickness) of Prokarin is very important. Thick
Prokarin exerts a very weak effect; where as thin (runny) Prokarin
can cause a very transient effect as well as rapid pulse, stomach
pains, dizziness, and faint feelings. Prokarin should be fluffy
in consistency like foam shaving cream. Holding the tip of the syringe
right down on the patch at a 45-degree angle, the Prokarin should
come out like a foam shaving cream. If it comes out in a column shape
like toothpaste or a spaghetti noodle, it is too thick and will exert
only a weak effect. Histamine is involved in the livers metabolism.
If you are deficient in Histamine, your liver may not metabolize as
efficiently as most people, thus thick Prokarin may act more
potent in the beginning as it is not cleared from the system as quickly
as it should be. As the liver becomes more efficient, this same thick
Prokarin becomes too weak in potency to produce any improvements.
Talk to your pharmacist regarding the need for a fluffy consistency
of the Prokarin. If your Prokarin is any other consistency
than a foam shaving cream or stiff whipped cream, notify your pharmacy.
Note to the Pharmacist: The consistency of the Prokarin must
be checked from the 1 ml syringe, not the 60 ml syringe.
If your Prokarin is moist but feels sandy and gritty when
you rub it into your skin, then the caffeine may not be ground fine
enough. This can result in symptoms of dizziness, orthostatic hypotension
(decrease in blood pressure when you go from a sitting to standing
position), rapid heart rate, and overall decreased effectiveness
of Prokarin. If you notice this sandy-gritty texture, please
notify your pharmacist.
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Getting the patch sealed
It is very important that the patch is sealed from air. Air will
crystallize the histamine very rapidly and it wont go across
the skin. You will know if you are having a problem with this if
when you change the patch, the cream that is left is as smooth as
lotion, but when you rub it in there is a white chalky residue on
the skin. If this is happening follow these steps:
- The best place to apply the patch to seal it from air is on the
front of the thighs. The reason being is that the front of the thigh
has a very large muscle going in one direction. When you have different
muscle groups in an area it is difficult to get the patch sealed.
As the different muscle groups move they will wrinkle the patch.
- Use the middle section of the thigh, dont get too close
to the groin or knee as the muscle tapers.
- Apply the hydrocortisone to the area, at least 15 minutes before
you apply the patch, especially if you are getting redness and irritation.
Make sure when you apply the hydrocortisone cream that you use only
about 1/16th of an inch so it just barely peeks out of the tube.
That will cover about a 3-inch square area on your leg. If you use
too much you might decrease the absorption of the Prokarin
and also interfere with the patch sealing tight to the skin.
- It is very important that your knee is perfectly straight when
applying the patch. Do it in a standing position with your knee
straight, or if sitting down, elevate your leg on a chair to make
the knee straight. You may have to put the foot on a pillow if you
are lying in bed, to get the knee perfectly straight. If the knee
is flexed (bent) at all, the thigh muscle is elongated. You need
the muscle to be in its shortest position when you apply the patch.
If you apply the patch with the thigh muscle in its longest position,
it will wrinkle up the patch and wick air under it when you move
your leg and shorten the muscle. This will quickly cause the medication
- While your leg is still straight, look to see if there is any
rippling or dimpling on the edge of the patch. If there is, immediately
peel up half of the patch (only half) and pull it back down with
tension. (If you peel up the whole patch you will have difficulty
getting it to stick). Apply tension on the other side of the patch
as you do this. If you need to adjust the patch, you must do it
immediately upon putting it on otherwise you wont get it to
stick, even 10 or 15 minutes later it wont stick again.
- If you are still having difficulty sealing the patch, you may
need to secure the patch with HyTape®. You can obtain this from
your pharmacist in a 3 wide roll. Peel the tape back and cut
it about 5 inches long so that it is about 2 inches longer than
the patch. I secure my patch with this tape in the summer when I
am moving around working in the yard, sweating, or if its
humid. If you are a person whose skin repels adhesive tapes, try
using the Skin Prep Barrier Wipe®. It comes in an individual
foil packet like an alcohol wipe. You can get it from a pharmacy
that sells ostomy supplies. When using the Skin Prep Barrier Wipe®,
remember these steps:
- Apply hydrocortisone cream as usual, 15 minutes before.
- Then, just before you apply the patch, hold a quarter down where
you plan to put the Prokarin.
- Take the Skin Prep Barrier Wipe® and wipe around the quarter.
The quarter is used to ensure that the Skin Prep Barrier Wipe®
doesnt get applied where the Prokarin is going to be placed.
- Wait about 10-15 seconds for the barrier wipe to dry.
- Flip up the quarter on its edge and apply the Prokarin
directly from the syringe onto the skin, where the quarter was.
- Then take the quarter completely off and apply the patch, still
making sure that your muscle is in its shortest position.
A good indicator that air is getting under the patch is that after
about 4 hours of wearing your patch, it starts itching and you start
to get some irritation at the patch site. This usually means that
the patch has come loose slightly. If the patch moves at all on
the skin, it becomes an irritant to the receptors in the skin and
you will start to get a site reaction. If you experience this a
few hours after applying your patch, check your patch and see if
it has come loose at all. If it has, apply some HyTape® over
the patch to secure it.
Often the patch adhesive leaves a residue on the skin, which is
difficult to remove. The easiest way to remove it is with soap and
water in the shower and then after your shower, while you are drying
off, you can usually just rub it off with your hand.
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Site reactions to the patch
The majority of the people using Prokarin have a site reaction,
a slight irritation or rash at the site. A little bit of a welt
may be visible when you change the patch. You can minimize the site
irritation by applying about a 1/16th of an inch of hydrocortisone
to the site 15 minutes prior to applying the patch. Some peoples
skin is not too sensitive, so they can get by with applying the
hydrocortisone cream only 5 minutes before. But if you are getting
a site reaction apply the hydrocortisone 15 minutes before the patch.
The hardest part is remembering where you applied the hydrocortisone!
You can mark the area with a pen or a little piece of tape.
If you continue to get a site reaction try another site. Some sites
may be more sensitive than others. If a site gets irritated, avoid
that site and a 3-inch diameter area around it until the irritation
resolves. You can also use the outside of your thighs, although
it is a little harder to get the patch sealed there because of other
muscle groups in this area. Generally the skin is less sensitive
on the outside of the thigh.
Site irritation may also be a result of the patch loosening. If
the patch loosens the slightest bit, it will cause skin irritation.
Check your patch and if you see a little bit of adhesive residue
showing on the edge of the patch, it has probably loosened. Apply
a 5 long piece of HyTape® tightly over the patch to seal
it down tight again. This should decrease or stop the irritation.
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As a rule of thumb, if you are seeing changes in your symptoms
while using the Prokarin then you are probably absorbing an
adequate amount. Many people worry that when they change the patch
they see a lot of cream left over and it is hard to judge how much
has been absorbed. Generally the cream that is left is mostly the
transdermal gel (cream) used to slowly release the active ingredients
across the skin. Rub in this remaining cream as it may still have
some active ingredients in it. When you remove the patch, the cream
is usually stuck on the patch; wipe the cream off the patch and
onto your skin. It usually takes 2-3 rubs with the palm of your
hand to rub the cream into the skin and it should totally vanish.
There should not be any cream left. If it takes a lot of rubbing
to get the cream to rub in, then you are probably not absorbing
very well. If you are not absorbing well, the Prokarin might
be too thick. (See the Section on Consistency, page 1). If the Prokarin
is of a foam shaving cream consistency, the patch is sealed tight
from air, and you still are having very little absorption, try applying
the patch in a different area. Some people may have better absorption
from sites on their chest or arms. If after trying various sites,
you still are not getting adequate absorption, talk to your pharmacist
about a niacin cream that can be applied to the skin just prior
to applying the Prokarin patch.
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Histamine stimulates the production of melatonin, which is essential
in fat metabolism. It is important that you get enough fats in your
diet as the majority of the myelin is made up of fats called phospholipids.
It is important that you have a balance of unsaturated and saturated
fat in your diet. Unsaturated fats are liquid at room temperature
like vegetable oil, flaxseed oil, primrose oil, and fish oil. Saturated
fats are solid at room temperature and are in most animal fats like
butter, lard, red meat, cheese, etc. Research shows that diets high
in unsaturated fats and low in saturated fats can result in lipid
peroxidation. Lipid peroxidation is toxic to the myelin and nerve
cell membranes. The trend has been to increase the unsaturated fats
and decrease the saturated fats in the diet. I wonder if this trend
is contributing to the prevalence of neurological disorders. I personally
eat red meat 3-4 times a week, butter, cheese, eggs, etc. as well
as fish, and my lipid peroxidation results were low which is desirable.
This may vary from person to person. If you have been on the Swank
diet with good results, yet dont see any improvement when
you try Prokarin, consider adding some animal fat to your
diet. Also, be sure to eat frequent small meals as Prokarin
can lower your blood sugar.
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A good multivitamin and mineral supplement is important. Rule of
thumb, a good vitamin and mineral will look the same on the inside
as it does on the outside when the vitamin is cut in half. I personally
have been using Nutrilite® vitamins for several years. Talk
to your pharmacist about a good brand of multivitamin and minerals.
Vitamin B-12 is essential in the making of myelin components. Talk
to your pharmacist about the type and dosage of Vitamin B-12 that
would be best for you. Calcium and Magnesium are important to supplement
when using Prokarin. Research studies show that Histamine
can lower the blood calcium level. Signs and symptoms of low blood
calcium are muscle spasms, stiffness, and numbness and tingling
in the hands and feet. Calcium is difficult to absorb, so it is
that calcium supplements are taken with meals to increase absorption.
Calcium is very constipating, but magnesium helps to counteract
this. Some forms of calcium are more absorbable than others, so
talk to your pharmacist about brands and dosage recommendations.
Supplements commonly recommended by Dr. Gillson:
If you are not on a lot of supplements, dont start all this
at once! I suggest adding just one or two things at a time, and
waiting a week to see if there is any adverse reaction (headache,
nausea, worsening symptoms) before adding more things.
B Complex containing 100 mg of thiamine per capsule: one
twice daily. (B Vitamins in general are beneficial for the nervous
system and for energy generation) Niacin Three or four times daily,
on an empty stomach. Start with one 100 mg tablet per dose and increase
the dose until you develop a flush. It shouldnt be unpleasant.
If you dont develop a flush with 1000 mg dose, dont
Niacinamide may be helpful for spasms in some individuals.
Try 250-500 mg every 3-6 hours up to a maximum of 3000 mg/day. Niacinamide
is a different chemical form of niacin and is much more active in
Sublingual B12: 1000 micrograms three times daily
Folic acid: 400 micrograms, twice daily.
Biotin 15-20 mg/day (Thorne makes something called Biotin-8,
one twice daily would do it). Biotin has been shown to be beneficial
for neuropathy in diabetics.
Chelated calcium 1200 1500 mg/day
Chelated magnesium 750-1000 mg/day (sometimes causes diarrhea-if
occurs, cut back). Magnesium is also a cofactor in the syntheses
of histamine from histidine.
(Chelates include malate, citrate, succinate, taurinate)
Please note corrections to Supplements page 7 in soft-bound
handout booklet. The booklet should read as follows:
Recommendations for individual supplementation of Vitamins E, D,
and A have been removed. These are fat-soluble and can accumulate.
Thus, these vitamins should not be supplemented separately, as they
are generally found to be present in adequate amounts in a quality
multivitamin and mineral supplement.
MSM (methylsulfonylmethane) 1000 mg, three times daily for
liver and adrenal support and muscle spasms.
SAMe 200 mg once daily some evidence that is supports
Anhydrous betaine (e.g. Thorne Research Methylguard) 600
mg twice daily. Boosts SAMe production.
Melatonin 1 mg sublingual tabs, 2 at bedtime. It is an important
Good quality multivitamin and multimineral without iron ($15-$20/month,
not Centrum-type e.g. DaVinci Spectrum) Pancreatic enzymes with
each meal. At the Tahoma Clinic, we typically aim for around 100,000
units each of Protease and Amylase, and around 25,000 units of Lipase
per meal. Some examples are Lipanase by AMNI, Dipan-9 by Thorne,
and BioZyme by PhytoPharmica. Viokase 16 is an enzyme complex available
by prescription. These enzymes were never intended to pass through
your stomach anyway, so I dont think it matters whether you
take them before, during or after meals. It makes the most sense
to me to mix them in with your meal, so at least some of the dose
makes it into the small intestine with your food. Betaine HCI with
pepsin* 10 grain capsules (2 grains of pepsin), two with each meal,
between the first few bites of food. Helps with digestion. Interestingly,
histamine is one of the major triggers of acid release in the stomach.
Amino acids 5 grams per day (amino acids as opposed to intact whey
or soy protein). All patients should consider amino acid supplementation.
Especially consider amino acids if you are underweight, have lost
muscle mass or have pressure sores. (SeaCure hydrolyzed fish protein,
10 caps per day is an excellent choice as is Twenty Amino Blend
or Twinlab. All are available at the Tahoma Clinic Dispensary.)
Taurine in particular may help spasms. Take 500 mg, 1-2 three times
daily on an empty stomach Injectable B12, folic acid, thiamine and
liver extract In consultation with your doctor.
PADMA Basic: 2 tabs, three times daily (This is fairly expensive,
$68/month at Tahoma Clinic Dispensary. It is a Tibetan blend of
19 different herbs which stimulate the circulation and immune system,
and exert antioxidant effects.)
Chrysin (passion flower) 500 mg capsule three times daily may help
Kava Standardized extract, 70-100 mg, 2 or 3 times daily. May sedate.
Dont take with alcohol or prescription tranquilizers.
∗ Betaine has many liver supporting and neurologic functions over
and above whatever effects it has on the stomach acid. I think Prokarin
may stimulate gastric acidity on its own in some cases, so the betaine
is recommended here more for liver and brain support. It may irritate
the stomach initially. If so, use just one cap per meal for a few
days before going to 2. Dont try full strength betaine (5-7
capsules/meal) without the guidance of your doctor. It may be indicated
in some cases.
Thymic proteins, especially live-cell extracts are another
avenue which can be explored, although again, they are not a first-line
intervention, and are expensive.
Some of these supplements are hard to find elsewhere, but are available
from the Tahoma Clinic Dispensary 252-850-5661 or 888-893-6878.
the on-line store may be accessed by going to www.tahoma-clinic.com
and clicking on Dispensary.
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You must wear 2 patches a day in order for Prokarin to be
effective (unless your liver metabolizes things very slowly and
your pharmacist and doctor have determined that you can only tolerate
1 patch). It is important to apply the first patch as soon after
rising in the morning as possible. Then 8 hours later remove that
patch and put the next one on. The active ingredients in Prokarin
are calculated to be released slowly over 8 hours and at the end
of those 8 hours most of the active ingredients have been absorbed.
For the most part, the only thing that remains is the transdermal
cream. It is important that when you change the patches, try not
to go more than 8 to 9 hours before you put the second patch on.
If you go greater than 9 hours, you may have a decrease in your
blood level of Histamine. You can leave the second patch on all
night if it is not bothering your skin. It is important that you
wear the Prokarin patches for the entire time that you are
up, alert, and awake. You can take a nap while using Prokarin.
There is much more demand for Histamine during our alert, awake
hours, and much less demand for it when we are sleeping. In order
to get the most benefit from Histamine you need to apply the first
patch in the morning and then after 8 hours, remove it and put another
one on and wear it for the rest of your waking hours.
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Swimming with the patch on
Some people like to swim every day. There are certain things you
can use to help waterproof the patch. It is important that you get
the patch sealed from water. Remember the transdermal cream that
is used in the Prokarin to carry the active ingredients across
the skin will also carry all other things across the skin. If you
get things like chlorine or soap under the patch, you can get an
alkaline burn from them. The Tegaderm® dressing has been successful
for some people in sealing the patch from water. You can get it
in a 4 x 6 inch diameter, which you apply directly over the patch.
The important thing is to apply the Tegaderm® at least one hour
prior to going in the water, because it takes the heat of the skin
to get it to form a good seal. Some people like to reinforce it
with a waterproof tape such as Johnson and Johnson®. Another
tape you can use is HyTape®, which you can obtain from the compounding
pharmacist who supplies your Prokarin. You can get this tape
in a 3-inch wide roll, cut the tape about 2 inches longer than the
patch. Cut 2 strips and apply them directly over the patch so that
you have at least 1 inch of HyTape® all around the outside of
the patch to help seal it from the water.
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Other medications used concomitantly with Prokarin
Discuss this with your pharmacist and your doctor. Prokarin
contains Histamine. In particular anything that blocks Histamine
2 receptors is going to interfere with the effectiveness of the
Prokarin. Histamine blockers include medication to decrease
stomach acid, such as Zantac®, Pepcid®, and Tagamet®.
It will say on the package if it is a Histamine blocking agent and
these need to be avoided. Also, anti-spasmodics such as Zanaflex®
and Baclofen® at higher doses can also decrease the effectiveness
Avoid supplements that contain licorice root. Many Chinese herbs
have licorice root in them. Licorice root may stimulate Histamine3
receptors, which can tell the body to turn down its Histamine production.
This can decrease the effectiveness of Prokarin.
If you have esophageal reflux (heart burn) you may take antacids
such as Tums®. This wont interfere with the action of
Prokarin. But as time goes on, you may find less reflux problems
because as the Histamine is replaced in the body, it will stimulate
gastric acid production. The increased acidity in the stomach increases
the tone of the sphincter between the stomach and the esophagus,
closing the sphincter tight so that food and acid dont regurgitate
back into the esophagus.
Occasional use of nasal allergy type of antihistamines does not
seem to interfere with the effectiveness of the Prokarin because
antihistamines block the H1 receptors not the H2 receptors.
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- Prokarin is very temperature sensitive. The ideal storage
temperature is 40-42 degrees F. It is best to store the Prokarin
in the door of the refrigerator with a refrigerator thermometer
on the same shelf of the door as the Prokarin. If Prokarin
comes in direct contact with ice or if it is exposed to temperatures
below 36 degrees F, it may be ruined. If it becomes thin like milk
or has a watery substance in the syringe, notify your pharmacy;
your Prokarin has likely gotten too cold. Also if when you
remove your patch, the Prokarin has a clear liquid like water
droplets around a white gummy paste, then the Prokarin has
separated, again probably due to excessively cold temperature. Again,
notify your pharmacy if this occurs.
- When traveling with Prokarin, take only as many doses
as you will need (allowing a couple of extra doses just in case
a dose is wasted accidentally). An insulated 6-pack carrier works
well when traveling. Place a zip lock bag of ice in the bottom of
the carrier. Then put the needed number of Prokarin syringes
in an amber zip lock bag. (Ask your pharmacy for an extra amber
zip lock bag.) Wrap the amber zip lock bag of Prokarin in
a Styrofoam® wrap or bubble wrap so that there are at least
3 layers of Styrofoam® or bubble wrap around the amber bag.
Secure the wrap around the Prokarin with a rubber band. Place
the Prokarin, which is now protected by Styrofoam® or
bubble wrap, on top of the ice in the bottom of the carrier. Then
place another zip lock bag of ice on top of the wrapped Prokarin.
It is wise to put a refrigerator thermometer in the carrier at the
same level as the Prokarin to monitor the temperature.
- If you plan to put your Prokarin in a refrigerator in a
motel room or at your final destination, be sure to check the refrigerator
temperature with your thermometer for at least 1 hour before transferring
your Prokarin from the insulated 6 pack carrier to the refrigerator.
Many refrigerators may be set too cold.
Please call your pharmacist to provide you with a video that demonstrates
the proper storage for traveling as well as how to apply the patch.
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Signs that indicate Prokarin is working for me:
Heat Tolerance: Histamine is the heat stress regulator
for the body. By supplementing Histamine to a body that is deficient
in this neurotransmitter, you would expect to see the body tolerate
heat again, such as a hot bath or shower. If you over expose yourself
to heat, you will use up Histamine. As your body temperature increases,
your need for Histamine also increases. You need to adjust to heat
gradually and watch for changes. Maybe you will now be able to tolerate
a little warmer temperature in your bath or shower without getting
wiped out or exacerbating your symptoms. If you live in an area
that has hot seasonal temperatures, you may find that you will need
a higher or more frequent dosing schedule during these hot temperatures.
Talk to your doctor about this.
Are you sleeping better? Are you dreaming again? Are you remembering
your dreams? Histamine stimulates the production of melatonin.
Low levels of melatonin interfere with the Rapid Eye Movement (REM)
stage of sleep. This is a very important stage of sleep during which
our body repairs itself. Melatonin levels fluctuate throughout the
night and day and it is the swing from high to low levels that stimulate
our body to go into the REM stage of sleep. If your melatonin levels
are low, there is not enough of a swing from high to low to induce
REM sleep. These increased levels of melatonin due to the supplementation
of Histamine through Prokarin may make you feel drowsy for
the first few days after starting Prokarin. Your body just
needs some time to adjust to the higher levels of melatonin.
Decrease in Pain: If you have pain, has your pain decreased?
Histamine is an analgesic for the body.
Decrease in Fatigue: Do you notice a decrease in your fatigue?
Maybe you can go shopping a little longer, or stay up later with
the family. Maybe you just dont feel as wiped out. Histamine
is a potent stimulator in our body to make cyclic AMP. Cyclic AMP
is necessary to every cell in our body every second just as oxygen
is. It is also vital to the myelin producing cells in the central
nervous system. The primary avenue for our body to make cyclic AMP
is through Histamine, but if this system is defunct then our body
has a backup system. The backup system is our body breaks down its
energy molecule, ATP, to make the cyclic AMP. This depletes our
body of its energy molecule so a person may experience the overwhelming
fatigue. By giving the body back the Histamine, the bodys
energy molecule is no longer being used up and the fatigue lessens.
Stress Tolerance: Can you tolerate some stress a little
better without it wreaking havoc on your symptoms like it did prior
to being on Prokarin? Histamine is a major stress regulator
for the body. The more stress you encounter, the more Histamine
you need. Emotional, physical, and environmental stress increases
the bodys need for Histamine. Increased stress or prolonged
stress may tap out your bodys supply of Histamine and the
usual dose of Prokarin may no longer be adequate. Therefore you
may notice increased symptoms during stressful periods. If you are
a female, you may notice an increase in symptoms during, or just
before your menses. If you are experiencing a prolonged period of
stress, such as an emotional crisis etc, you may want to consult
with your doctor to see if you should adjust your Prokarin
dose to help accommodate your bodys increased need for Histamine
during this time.
Improvement in Motor Function or Sensory Function: Histamine
is a major neurotransmitter for the body, as well as regulating
many other neurotransmitters in our body. A neurotransmitter is
a chemical that is necessary to send a message down a nerve pathway.
Just like muscles, the nerve pathways atrophy (shrink) when we dont
use them. The only way to build these atrophied nerve pathways is
by repetitively trying to send messages down them. This takes time
and diligence. Please refer to the section on Exercises for more
Do Others Notice a Difference in You : Ask your family
and friends if they notice any changes in you, such as a little
more life behind your eyes, you engage in conversations more, or
you all around look better? They will probably notice the subtle
changes, which you may have overlooked. Remember, as your body moves
toward normal it takes a conscious effort to notice it. So maybe
changes are occurring, but you arent consciously aware of
it. Here is an analogy: Our hands move several times a minute and
we are not even aware of their movements. But if we have a hand
that is tingling, or numb, we are aware of that hand every second
because it is abnormal to the body. A lot of times a significant
other or a friend will notice the difference before you will. Also
you may have your heart set on getting up and out of that wheelchair,
so you might not notice the little changes that are occurring. Look
for the little subtle changes. Please see the section on exercising
nerve pathways if you havent been doing the exercises. Perhaps
this is the variable that is missing.
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The exercises to build back the nerve pathways consist of concentrating
on sending a message from the brain to a part of your body that
isnt functional, trying to make it work. Repetitively trying
to send these impulses down the nerve pathways is what causes the
dendrites to grow again.
For example, if you cant move your toes, think hard:, Im
going to move my toes. Picture the impulse forcing its way
down the nerve to the non-functional part, like a flame burning
down a fuse. Even though you might not be able to move the toes,
relax 5-10 seconds and then concentrate hard again at trying to
send the message to your toes. The key is repetition. Do these exercises
5-10 times per set, 3-4 sets per day every day. Apply this same
type of exercise to other parts of your body, such as, trying to
rhythmically tap your feet on the floor, or touch your thumb to
each of your fingers. Another exercise is to stand in front of your
walker and tell yourself, Im going to stand up straight,
put my feet together and let go of the walker. Even if you
can only let go of the walker for an instant, thats okay.
Relax 5-10 seconds and try again.
Soon there will be a video available from your pharmacy that compounds
Prokarin, which demonstrates exercises that are used by professionals
who teach kinesthetic exercises to rebuild nerve pathways.
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Frequently Asked Questions
I have been on Prokarin for one month and no changes,
good or bad have occurred in my symptoms
I have been on Prokarin for one month and no changes,
good or bad have occurred in my symptoms
- Ask yourself, are you sensitive to heat, does heat bother
you? In other words if you take a hot bath or shower, does it
worsen your symptoms? If it does we need to find the missing
piece of the puzzle. If you are heat sensitive this means that
you may be deficient in Histamine because Histamine is a heat
stress regulator for the body. So if heat worsens your symptoms,
it may indicate that your body doesnt have enough Histamine
because as our body heats up, it needs more Histamine. Histamine
is being supplemented in Prokarin. If Histamine is supplemented
to a body that is deficient in Histamine, the person may see
a lessening in heat intolerance.
- Are you applying the patch in the morning as close to
when you wake up as possible and 8 hours later are you removing
that patch and applying the second patch? Please see the section
on Patching Times.
- When you remove the patch, is the cream as moist as a
lotion and does it rub into your skin and disappear, or does
it leave a white chalky residue on the skin after you rub
it in? Generally when you remove the patch, the cream that
is left should simply rub into your skin with only 2-3 rubs
of the palm of your hand and vanish like a lotion. If it leaves
a white chalky residue, then air has gotten under the patch.
If this is happening, please see the section on Getting the
- Are you storing the Prokarin properly? Prokarin
needs to be stored in the refrigerator, preferably in the
door with a thermometer right on the shelf with it. The temperature
should be 40-42 Degrees Fahrenheit optimal. If the temperature
is 36 Degrees Fahrenheit or less, the Prokarin will
be ruined. If you are having problems with this or suspect
this, please see the section on Storage for information.
- The consistency of Prokarin is of utmost importance
in regards to its potency. Hold the syringe with the tip touching
the patch at a 45 Degree angle and press on the plunger of
the syringe. The Prokarin should come out of the syringe
looking fluffy like a foam shaving cream or stiff whipped
cream. If it comes out of the syringe in a column like a toothpaste
or a spaghetti noodle, then the Prokarin is too thick
and will exert a weak effect. The thicker the Prokarin,
the slower it releases the active ingredients, and if the
ingredients are released too slowly they will not produce
any therapeutic effect. It is very important that the Prokarin
be of a foam shaving cream or stiff whipped cream consistency.
If your Prokarin doesnt have this consistency,
notify your pharmacy.
- Shipping is also a variable. Prokarin is very temperature
sensitive. There is a possibility that the Prokarin
could have gotten too cold during shipping especially in cold
weather. A good indication of this is when you push on the
plunger of the syringe to dispense the Prokarin, it
may look watery, thin, or milky. When you take the patch off,
you may notice a clear liquid separated from the white cream,
which leaves a gummy or clumpy white residue. If this is the
case, the Prokarin has probably frozen and you need
to contact your pharmacy.
It is harder to determine if the Prokarin got too
warm in transport. 40-42 degrees F is the perfect temperature
for Prokarin. If it had gotten up to 50-54 degrees F
during shipping, it probably will still remain effective,
but may not last the whole 30 days. The shelf life of Prokarin
shortens when exposed to higher temperatures. If at any time
it was greater than 50 degrees F, contact your pharmacist
about getting new Prokarin.
If you suspect that your Prokarin has been exposed
to temperatures outside the ideal range, please see the section
- If you are applying Prokarin, of the proper consistency
which as been stored at the right temperature of 40-42 degrees
F, two times a day for 8 hours each time, and you are getting
the patch sealed from air so that the cream disappears like
a lotion, then perhaps it could be your diet.
Are you on a low fat diet?
Do you take the recommended supplements?
Please refer to the recommended Supplements and Diet section.
If all of these variables seem to be under control and you
are not seeing any changes in your symptoms good or bad, then
perhaps you should talk to your doctor, as it is possible
that your dosage needs to be changed.
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When I first started using Prokarin, I saw improvements
for the first couple of weeks to a month, and then there was
a gradual loss of these gains. The key word being gradual
Unfortunately Prokarin is a very fragile compound that
can lose its shelf life very easily even under optimum conditions.
If you saw improvements with your first batch and then not
with your second batch look for a couple of things:
- Is the consistency of the Prokarin the same as
the last batches? Is it fluffy like foam shaving cream or
thicker like a column of toothpaste or a spaghetti noodle?
See the section on Consistency.
- Are you on a low fat diet? See the section on Diet.
- Is the temperature of your refrigerator 40-42 degrees F?
See the section on Storage.
d) Is it near the end of your 30-day supply of Prokarin?
Prokarin has a shelf life of 60-70 days from the date
it was compounded, under optimum 40-42 degrees F conditions.
Many variables can influence the shelf life.
- Are you taking the recommended supplements? See the section
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I started Prokarin and after about 3 days all my symptoms
got worse including numbness, tingling, fatigue, etc.
- The key word here would be abrupt. If you see an abrupt
increase in symptoms or decline in your condition it may mean
that the Prokarin dose is too high for you and it has
triggered the body to decrease its own production of Histamine.
Discuss this with your doctor and pharmacist, as you probably
need a change in your dosage.
- Prokarin is supplementing something your body already produces
(Histamine). Whenever you supplement something your body naturally
makes, you want to give just enough to the body to keep it
in its normal range. If you give too much back artificially
and get the level too high in the body, it will trigger the
bodys feedback mechanism, which tells the body that
there is too much of this chemical. Because of this, the body
wont produce as much Histamine. When this happens, the
bodys own production of the Histamine decreases and
now you are trying to get by on the amount of Histamine that
is in the patch. This may be why you see a sudden worsening
of your symptoms because you are trying to get by on less
Histamine than you were prior to being on Prokarin.
Now, if you see improvement for the first 2-3 days and then
the symptoms increase abruptly, perhaps your liver doesnt
metabolize quite as rapidly as most people and you will start
to get an accumulative effect. The first day you feel better,
second day even better, and by the third day or fourth day,
you hit a brick wall where all of your symptoms come crashing
back. Perhaps your liver could not metabolize in 24 hours
what you took in from the Prokarin, so you got a carry
over effect. By the third or fourth day the level was too
high and you triggered your feedback mechanism to turn down
your bodys production. You need to talk to your doctor
and pharmacist about adjusting your dose and bringing it down,
to the amount your liver can metabolize and then slowly titrating
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When should I talk to my doctor about increasing my dose?
We have a tendency to believe that if a little is good then
more is better, but that is not generally the case when you
are supplementing something that the body already makes. The
body must keep all things within a balance and we want to
maintain that balance. Rule of thumb, as long as you are seeing
slow steady subtle changes, remain on the lower dose.
If you have been experiencing improvements and now your
progress seems to have plateaued, are you doing the exercises?
Are you on a low fat diet and / or taking the unsaturated
fat supplements, such as flaxseed oil, primrose oil, salmon-omega,
etc? All of these things can influence improvement. Please
see the sections on Supplements, Diet, and Exercises.
Our body tries to maintain homeostasis. Change is stressful
on the body even if it is good change. The body tries to level
out change creating a plateau. So whether you are building
muscle or trying to lose weight, your body does it in a stair-step
fashion. For as you initiate a change, your body struggles
to level out the change and you experience a plateau. The
body would be happy just staying on this level stair, so you
must take measures to force the body off the stair and continue
to progress with change. For example, when you are dieting
to lose weight, you limit your calories or change the type
of foods you eat to initiate weight loss. You lose a few pounds
very quickly, but then your weight loss plateaus because your
body is working to adjust to this change and create homeostasis
again. In order for you to start losing weight again, you
need to increase your exercise or further limit your calorie
intake, forcing your body to move off the level stair again
to the next step. This same concept applies to any change
while using Prokarin. If you feel you have reached a
plateau, try doing more exercises, assessing your diet and
balance of fat intake. If you continue to experience the plateau
after trying to challenge your body with exercises, then perhaps
consult with your doctor about increasing your dose of Prokarin.
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Can I do bee sting therapy with Prokarin?
Some people are using bee venom therapy and Prokarin
and have reported needing fewer stings with Prokarin.
It may be wise to stop stings when starting Prokarin,
then add stings; or if you choose to continue with bee stings,
start with a low dose of Prokarin and increase gradually
under the direction of your doctor.
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I have more energy, Im sleeping better, and I can tolerate
heat better, but Im still not walking better. Why is that?
Histamine is an important neurotransmitter (chemical) in
our body. Histamine is a heat stress regulator for the body.
It also is the chemical that stimulates the pineal gland to
make melatonin and cyclic AMP. Cyclic AMP is like oxygen to
every living cell, in that every cell needs it every second.
If your body doesnt have enough Histamine to make cyclic
AMP, your body has no other choice than to break down ATP
(the energy molecule for the body) to make cyclic AMP. This
results in the severe fatigue.
By giving back the Histamine chemical, the body can quit
robbing its energy molecule, so the fatigue may improve. Also
the body can start making more melatonin so the deep sleep
(REM state) can now occur. Restoring Histamine helps the body
tolerate heat again because now it can sweat.
Heat tolerance, fatigue, and sleep may all improve by just
giving back Histamine to the body that is deficient in it.
The motor function and sensory function improvements are dependent
on rebuilding of nerve pathways. Research shows that the nerve
pathways (dendrites) shrink with disuse, but by repetitively
sending messages over these nerve pathways the dendrites grow.
Please see section on Exercises.
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I am experiencing an increase in muscle spasms, stiffness,
numbness and tingling since I started Prokarin.
Research shows that Histamine can lower the blood level of
calcium. Thus, calcium and magnesium supplements are necessary
when using Prokarin. Please see section on Supplements.
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Caffeine bothers me.
Prokarin contains caffeine so if you dont tolerate
caffeine talk to your pharmacist and doctor about this. The
amount of caffeine in one 8-hour dose is equivalent to about
a half cup of regular strength coffee sipped over 8 hours.
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